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 主站首页 > 北京乙肝临床数据和样本资源库 > 疾病库介绍
疾病库介绍

依托单位:首都医科大学附属北京佑安医院

 

首都医科大学附属北京佑安医院在建国初期由彭真市长亲自规划建设,是以感染、传染及急、慢性群体为主要服务对象,集预防、医疗、保健、康复为一体的大型综合性医学中心。医院在人工肝支持、肝脏移植、艾滋病诊疗、中医治疗肝病等方面的技术水平为国内领先。并联合67家国内医院成立了《佑安医疗联盟》,创建了中国初级卫生保健基金会佑安肝病艾滋病基金,积极开展社会公益事业。佑安医院积极参与国际合作,成立了“中美肝脏移植协作中心”,“北京佑安医院——牛津大学合作基地”,“北京佑安医院——加拿大卡尔加里大学合作基地”。拥有8个硕士研究生点、4个博士研究生培养点和2个博士后流动站,在研学生近百名。佑安医院连续被评为全国卫生系统先进集体、首都精神文明建设标兵单位,荣获全国五一劳动奖状、全国三八红旗集体等光荣称号。时任总书记胡锦涛、总理温家宝、副总理刘延东、副总理吴仪、副总理王岐山、北京市委书记刘淇、卫生部长陈竺、党委书记张茅等党和国家领导人均先后亲临佑安医院视察指导,给予佑安人极大的鼓舞和鞭策。首都医科大学附属北京佑安医院将以搭建国际医药科技临床与转化医学高端平台为目标,促进医院发展,促进首都卫生事业的发展。
In the early days, Beijing You An Hospital, Capital Medical University was personally planned and constructed by the mayor Peng Zhen. The main target groups and key disciplines of hospital is infected ,infection and acute and chronic disease. On the technical of Artificial Liver support, Liver Transplantation, AIDS Treatment and care, Chinese medicine treatment of liver disease, etc, the hospital is in the first-class in domestic. Now has 750 beds.Has 17 clinical departments,16 medical departments.Joint 67 domestic hospitals set up a “YouAn Medical Union”.And created a China Primary Health Care Foundation named “YouAn liver disease and AIDS Fund”. Actively carry out social welfare services. And activily participate in international cooperation. Established China-US liver transplant coordination center, Beijing You An Hospital - Oxford University Cooperation Base, Beijing You An Hospital - University of Calgary, Canada cooperation Base. Has eight Master training points, four PhD training points, two postdoctoral, and a hundred students in study. The Hospital has received a number of honorary titles. Many party and country leaders come to inspect the hospital.As the target, Beijing You An hospital will build high-end platform for international cooperation.

 

资源库建设

乙型肝炎标本从建院之初开始留存,至2009年纳入北京市科技计划——“北京市乙型肝炎临床数据库和样本资源库建设”项目,以构建一个规模较大、资料完整、管理规范具有国际一流的“乙型肝炎临床资源和样本库及生物医学信息网络平台”为目标,以肝炎至肝癌的早期诊断标志物、肝癌早期患者免疫水平研究为方向。截至2013年底,储存标本数已超过65000份。以资源库为基础开展多项课题研究,包括“国家十二五计划”、“国家自然科学基金”、“国家科技重大专项”等,合作单位包括北京友谊医院、同济医院、北京大学人民医院等20余家知名医院。并与英国牛津大学、加拿大卡尔加里大学、美国华盛顿大学建立合作基地,引进海聚人才,共同促进标本库的开发利用,和转化医学的发展,已发表多篇具有国际影响力的文章,发表杂志包括《Blood》、《Nat Commun》、《J Immunol》等,并积极开发临床应用试剂盒,已取得国家专利。乙型肝炎标本库的未来发展将以高水平、高层次的合作开发利用为方向,促进首都卫生医药临床和科研事业的发展。
Hepatitis B samples retained from the beginning of the hospital construction. To 2009 , included in the Beijing Science and Technology Plan - "Beijing hepatitis B clinical databases and sample repository construction " project. As the goal, to build Hepatitis B clinical resources and sample libraries and biomedical information network platform, as a large -scale, data integrity, management practices, and world-class. Will be major in the research of early diagnostic marker of liver cancer and the immunization levels of liver cancer. Now the number of store specimens has more than 65,000 copies. As the basis , the repository carried out about 20 research projects, Including "National 12th Five Year Plan ", " National Natural Science Foundation of China ", " National Science and Technology Major Project ", etc. More than 20 co-operation hospitals, including Beijing Friendship Hospital , Tongji Hospital , People's Hospital Peking University. Also established cooperation basis with University of Oxford , University of Calgary , University of Washington. Has published many articles, including "Blood", "Nat Commun", "J Immunol" , etc. In the future, we will construct a high level of hepatitis B sample libraries , develop high- level cooperation .Promote the development of Capital Health Medicine clinical and research level.

病例入组标准:

① HBeAg阳性或阴性慢性乙型肝炎
入选标准:年龄小于45岁;HBsAg阳性,HBVDNA阳性,ALT>ULN。B超等检查除外肝硬化。初次应用或准备更换抗病毒药物。
②HBsAg或HBV携带者
入选标准:年龄小于45岁;HBsAg阳性,HBVDNA阳性或阴性(检测两次,间隔3个月),男性ALT<30U/L,女性<19 U/L。B超肝脾各项指标正常。有肝脏病理学检查结果更好。
③乙肝肝硬化
入选标准:代偿或失代偿期乙肝肝硬化患者
④乙肝相关肝癌
入选标准:乙肝相关原发性肝细胞癌
① HBeAg positive or negative chronic hepatitis B
Inclusion criteria : younger than 45 years old; HBsAg positive, HBVDNA positive, ALT> ULN. B ultrasonic examination except cirrhosis. Initial application or ready to replace antiviral drugs.
② HBsAg or HBV carriers
Inclusion criteria: younger than 45 years old; HBsAg positive, HBVDNA positive or negative (checked twice, interval 3 months), male ALT <30U / L, women <19 U / L. B-normal indicators of liver and spleen. Better results in liver pathology.
③ liver cirrhosis
Inclusion criteria: compensatory or decompensated liver cirrhosis
④ hepatitis B-related liver cancer
Inclusion criteria: HBV-related hepatocellular carcinoma

 

样本类型:

以血液样本为主,包括血液、腹水、肿瘤组织、等。血液样本包括:全血、PBMC、血浆、血清、DNA等。
The specimens include blood,ascites,tumor tissue,and so on.Blood simple is mainly,include:whole blood,PBMC,plasma,serum,DNA,etc.

 

友情链接: 北京市科学技术委员会 | 首都医科大学 | 中国人类遗传资源平台 | BBMRI | ISBER | P3G | OBBR | caHUB | 深圳国家基因库 | 生物银行
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